Best Of is the first greatest hits album by American hip hop recording artist 50 Cent. It was released on March 31, 2017, by Shady Records, Aftermath Entertainment and Interscope Records. The compilation includes tracks from five of his previous studio albums: Power of the Dollar (2000), Get Rich or Die Tryin' (2003), The Massacre (2005), Curtis (2007) and Before I Self Destruct (2009). Also included are songs from the soundtrack to the film Get Rich or Die Tryin' (2005). It also includes the non-album singles "Get Up" and "I Get It In". 

Best Of anthologizes the majority of the singles that 50 Cent released during his joint deals with Eminem's Shady, Dr. Dre's Aftermath, and major-label Interscope. This is the first Shady Records album that does not feature Eminem on a song.